I shared in my first post the leading correlations to brain and nervous system cancers to be the following:
- Average Height: 70%
- Life Expectancy: 62%
- Recorded Alcohol Consumption: 60%
I have now investigated new hypothesis and came up with new, also high correlations that could lead to glioma (or not):
- Protein Consumption (kg/yr): 63%
- Carbs % of Diet: -68%
That's right, the higher the contribution of carbs to one's diet the lower chance to develop brain tumor. Of course I might be stretching my conclusion here. As I learned in statistics correlations do not mean causality. In fact the high % of carbs in a diet might just mean lower protein consumption, the potential cause (these do not look like independent variables).
This leads me into a new hypothesis: could protein consumption lead to cancer? When I combined all the variables into one multi-variate correlation, carbs and protein consumption had negative correlations to brain tumor while the other variables remained with positive correlations.
One of the leading theories about why we thrived as humans is the size of our brains. Large brains were only developed because we were able to support it with higher protein consumption as we evolved, enabling us to sustain the high energy levels required by the brain to function properly. Another theory, available in the book "Born to Run", is that by being able to run for very long distances we were able to hunt large, protein filled animals, feeding our growing brain.
What if one thing led to the next? As we ate more proteins new genetic mutations helped us develop our brains, but potentially our high level of activity enabled us to control the increase in brain size without it turning into a deadly tumor. One of my hypothesis is that heat-shock proteins (HSPs) might help us as a tumor suppressor gene helps us fight cancer cells. In fact new experimental brain tumor vaccines are based on HSPs, which levels are increased after physical exhertion. In fact after half-marathons HSPs levels increase and remain high, and given its function, which is to restore damaged DNA after our body is exposed to high temperatures, I started believing in my crazy theory.
According to my neuro-surgeon I probably developed my brain tumor about 10 years ago, coinciding with a period of extreme physical inactivity from my part (I would play pick-up soccer or basketball once in a while).
I am not a professional scientist (not even an amateur one), but if a real scientist is looking for hypothesis I hope this one is worth investigating and leads into something, even if just into more research grants for scientists to investigate and help us living with glioma.
What exactly am I speculating again?
That a combination of being tall, high alcohol and protein consumption, and little physical activity (meaning not running at least say 20k/week) might be a potential cause for what I have, which would put all my tall friends in a risk group. I will keep running crazy correlations until I find more stuff. I tried to correlate polution with it all and could not get to a high correlation, so I will keep digging. If you know something that might help this amateur investigation please share it with me. Thanks!
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